AGING OF HEMATOPOIETIC STEM CELLS: UNREVEALED ROLE OF NEOGENIN-1/NETRIN-1 AXIS
The project granted by the Foundation for Polish Science within HOMING program.
: Project duration: 01 listopada 2018 r. - 29 lipca 2021 r.
Grant amount: 800'000 PLN
PI: Krzysztof Szade,
Laboratory of Stem Cell Biology,
Faculty of Biochemistry, Biophysics and Biotechnology,
Jagiellonian University, Krakow, Poland
​ Funded by the European Regional Development Fund
under the Smart Growth Operational Programme 2014–2020 (PO IR).
​
>>> AIMS OF THE PROJECT
Our aim is to identify molecular mechanisms responsible for hematopoietic stem cell (HSC) interactions with the specific bone marrow niches. We want to understand how these interactions change with age and whether these changes drive HSC deterioration.
Therefore, the overall objective of our proposal is to test whether there is a distinct bone marrow niche
that drives expansion of age-related myeloid-biased HSCs.
>>> OUR ACHIEVEMENTS
​The results of the project were published:
