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Our current grants

Keap1-dependent proteopathy as a unifying mechanism of vascular dysfunction.

Opus, National Science Centre. 
PI – Anna Grochot-Przęczek (to be completed in 2026).

What does your blood remember? The memory of hematopoietic stem cells.

ERC Starting Grant. 
PI – Krzysztof Szade (to be completed in 2027).

Endothelial cells in the composition of hematopoietic niche: the versatile choir or specialized soloists?

Maestro program. National Science Centre. 
PI – Alicja Jozkowicz (to be completed in 2024).

Development of the new strategy for the mobilization of bone marrow cells to the blood
for the treatment of hematopoietic disorders.

Lider program, The National Centre for Research and Development

Agata Szade (to be completed in 2024).

Heterogeneity and mechanisms of regeneration of endothelial cells in the bone marrow niche.

Diamond Grant, Polish Ministry of Science and Higher Education

Monika Gońka (to be completed in 2022).

Protein S-nitrosation as a trigger for DNA leakage from the nucleus: in the quest for a mechanism.

Preludium program. National Science Centre. 
PI – Aleksandra Kopacz (to be completed in 2023).

Heme metabolism in blood vessel wall - the influence on abdominal aortic aneurysm formation.

Sonata program. National Science Centre. 
PI – Witold Nowak (to be completed in 2023).

Cellular and molecular mechanisms driving the expression of mobilizing cytokines

Sonata program. National Science Centre. 
PI – Agata Szade (to be completed in 2023).

Fibrosis or senescence - why lack of transcriptionally active Nrf2 protects against colon dysfunction

Sonata program. National Science Centre. 
PI – Aleksandra Piechota-Polańczyk (to be completed in 2022).

Senescence or apoptosis – the role of miR-34a in endothelial cells.

Sonata Bis Program. National Science Centre.

PI – Anna Grochot-Przęczek (to be completed in 2023).

Tracing the roots of leukemia - how pre-leukemic hematopoietic stem cells contribute to acute lymphoid and myeloid leukemias?

Harmonia Program (partner: prof. Irving L. Weissman, Stanford University). National Science Centre.

PI - Krzysztof Szade (to be completed in 2022).

Heme and G-quadruplexes: an overlooked function of heme oxygenases?

Opus Program. National Science Centre.  

PI – Alicja Jozkowicz.  (to be completed in 2022).

Induction of endogenous G-CSF for mobilization of hematopoietic stem cells for transplantation.

DKMS Foundation.

PI – Agata Szade (to be completed in 2021).

DNA repair in hematopoietic stem cells: what is a role of nuclear heme oxygenase-1?

Harmonia Program (partner: prof. Irving L. Weissman, Stanford University). National Science Centre.

PI – Alicja Jozkowicz  (to be completed in 2020).

Aging of hematopoetic stem cells - unrevealed role of Neogenin-1/Netrin-1 axis.

HOMING program. The Foundation for Polish Science.

PI - Krzysztof Szade (to be completed in 2020).

All hands on deck”: the interdisciplinary approach against pancreatic cancer and its fibrotic stroma.

HOMING program (partner: PI - Paweł Ferdek, FBBB). The Foundation for Polish Science.

PI - Monika Jakubowska; MCB (to be completed in 2020).

Characterization of hematopoietic stem cell subpopulations with accelerated cell cycle – role of Neo-1 and HO-1.
Etiuda Program. National Science Centre.  

PI - Monika Żukowska. (to be completed in 2020).

Molecular mechanism of new apoptosis induction strategy in the experimental anticancer targeted therapy.

Etiuda Program. National Science Centre.  

PI - Damian Klóska. (to be completed in 2020).

Role of heme oxygenase-1 in melanoma initiating cells and melanogenesis.

Etiuda Program. National Science Centre.  

PI - Anna Kusienicka. (to be completed in 2020).

Targeting mechanisms of pancreatic cancer resistance against therapy: specific role of tumour microenvironment.

HOMING program. The Foundation for Polish Science.

PI - Monika Jakubowska; MCB. (to be completed in 2019).

Completed grants

  • Molecular mechanism of GDF-15 and SDF-1-induced angiogenesis – non-canonical role of Nrf2 transcription factor. Opus Program. National Science Centre. PI – Anna Grochot-Przęczek (completed in 2017) 

  • The role of Nrf2 in angiogenesis induced by GDF-15 and SDF-1 in vivo. Iuventus Plus Program. Ministry of Science and Higher Education. PI – Anna Grochot-Przęczek (completed in 2017) 

  • Heme oxygenase-1 and progression of melanoma: role in cancer initiating cells. Harmonia Program (partner: prof. Claudine Kieda, CNRS Orleans). National Science Centre. PI – Alicja Jozkowicz (completed in 2016) 

  • Endothelium in pathogenesis and therapy of modern-age diseases: from basic science to innovative endothelium-targeted drug". National Centre for Research and Development. Research task suprervisor – Alicja Jozkowicz (completed in 2015) 

  • Effect of heme oxygenase-1 on differentation of satellite cells: role of miRNA. National Science Centre. PhD student project for dr. Magdalena Kozakowska, PI – Alicja Jozkowicz (completed in 2012) 

  • Effect of reduced expression of PPARγ on function of endothelial progenitor cells in diabetes. National Science Centre. PhD student project for dr Jerzy Kotlinowski, PI – Alicja Jozkowicz (completed in 2012). 

  • Endothelial progenitor cells in therapy of ischemic hind limb in diabetic mice – role of oxygenase-1. National Science Centre. PhD student project for dr. Anna Grochot-Przeczek, PI – Alicja Jozkowicz (completed in 2012)

  • Molecular Biotechnology for Health. POIG. National Centre for Research and Development. Research task coordinator – Alicja Jozkowicz (completed in 2012)

  • Jagiellonian Centre for Experimental Therapeutics. POIG. National Centre for Research and Development. Research task coordinator – Alicja Jozkowicz (completed in 2012)

  • Role of HO-1 in induction and progression of esophageal carcinoma. National Science Centre. PI – Alicja Jozkowicz (completed in 2012)

  • The role of HO-1 translocation to the nucleus in the squamous cancer cells. Faculty of Biochemistry, Biophysics and Biotechnology. Research projects for young researchers and PhD students. PI – Agata Szade (completed in 2012)

  • Role of HO-1 in satellite cells. ADAMED Ltd. PhD student project for dr. Magdalena Kozakowska, PI – Alicja Jozkowicz (completed in 2011)

  • Effect of diabetes and major antidiabetic drugs on endothelial progenitor cells. ADAMED Ltd. PhD student project for dr Jerzy Kotlinowski, PI – Alicja Jozkowicz (completed in 2011)

  • Cytoprotective and proangiogenic gene therapy for critical limb ischemia in diabetic mice. Sunset Award. The Wellcome Trust. PI – Alicja Jozkowicz (completed in 2011)

  • Protective role of HO-1 in endothelial cells – construction of helper-dependent adenoviral vectors for a long term heme oxygenase expression. An International Senior Research Fellowship in Biomedical Science. The Wellcome Trust. PI – Alicja Jozkowicz (completed in 2010)

  • Role of HO-1 in stroma cells on development of melanoma. Ministry of Science and Higher Education. PhD student project for dr. Halina Was, PI – Alicja Jozkowicz (completed in 2009)

  • Polish innovative drug in therapy of diabetes based on the activation of PPARγ – preclinical studies. European Funds for Structural Development. Research task supervisor - Alicja Jozkowicz (completed in 2008)

  • Construction of gutless adenoviral vectors – effect of HO-1 on the wound healing. Ministry of Science and Higher Education. PI – Alicja Jozkowicz (completed in 2007)

  • Role of HO-1 in cytoprotective and anti-inflammatory effects of pentoxifylline. Ministry of Science and Higher Education. Research task supervisor – Alicja Jozkowicz (completed in 2007)

  • Role of peroxisome proliferator activated receptors-γ (PPARg) in angiogenesis. Ministry of Science and Higher Education. PI – Alicja Jozkowicz (completed in 2002)

  • Mechanisms of rejection of allogenic and xenogenic skin grafts in anuran amphibians. Ministry of Science and Higher Education. PI – Alicja Jozkowicz (completed in 1995)

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