Selected publications
Kusienicka A, Cieśla M, Bukowska-Strakova K, Nowak WN, Bronisz-Budzyńska I, Seretny A, Żukowska M, Jeż M, Wolnik J, Józkowicz A. Slow-cycling murine melanoma cells display plasticity and enhanced tumorigenicity in syngeneic transplantation assay. Neoplasia 2022, 36:100865, online ahead of print
Kopacz A, Kloska D, Fichna J, Klimczyk D, Kopec M, Jozkowicz A, Piechota-Polanczyk A. The lack of transcriptionally active Nrf2 triggers colon dysfunction in female mice - The role of estrogens. FRBM 2022, 192: 141-151
Kopacz A, Rojo AI, Patibandla C, Lastra-Martínez D, Piechota-Polanczyk A, Kloska D, Jozkowicz A, Sutherland C, Cuadrado A, Grochot-Przeczek A. Overlooked and valuable facts to know in the NRF2/KEAP1 field. FRBM 2022, 192: 37-49
Skulimowska I, Sosniak J, Gonka M, Szade A, Jozkowicz A, Szade K. The biology of hematopoietic stem cells and its clinical implications. FEBS J. 2021, Online ahead of print
Targosz-Korecka M, Kubisiak A, Kloska D, Kopacz A, Grochot-Przeczek A, Szymonski M. Endothelial glycocalyx shields the interaction of SARS-CoV-2 spike protein with ACE2 receptors. Sci Rep. 2021; 11(1):12157.
Szade A, Szade K, Mahdi M, Józkowicz A. The role of heme oxygenase-1 in hematopoietic system and its microenvironment. Cell Mol Life Sci. 2021 May;78(10):4639-4651.
Dumański JP, Harvaldson J, Davies H, Rychlicka-Buniowska E, Mattison J, Moghadam BT, Nagy N, Węglarczyk K, Bukowska-Strakova K, Danielsson M, Olszewski P, Piotrowski A, Oerton E, Ambicka A, Przewoźnik M, Bełch Ł, Grodzicki T, Chłosta PL, Imreh S, Giedraitis V, Kilander L, Nordlung J, Ameur A, Gyllesten U, Johannson A, Józkowicz A, Siedlar M, Klich-Rączka A, Jaszczyński J, Enroth S, Baran J, Ingelsson M, Perry JRB, Ryś J, Forsberg LA, Immune cells lacking Y chromosome show dysregulation of autosomal gene expression, Cellular and Molecular Life Sciences. 2021, Online ahead of print
Bukowska-Strakova, K. Włodek, J.; Pitera, E.; Kozakowska, M.; Konturek-Cieśla, A.; Cieśla, M.; Gońka, M.; Nowak, W.; Wieczorek, A.; Pawińska-Wąsikowska, K.; Józkowicz, A.; Siedlar, M. Role of HMOX1 Promoter Genetic Variants in Chemoresistance and Chemotherapy Induced Neutropenia in Children with Acute Lymphoblastic Leukemia. Int. J. Mol. Sci. 2021, 22, 988
Krzeptowski W, Chudy P, Sokołowski G, Żukowska M, Kusienicka A, Seretny A, Kalita A, Czmoczek A, Gubała J, Baran S, Klóska D, Jeż M, Stępniewski J, Szade K, Szade A, Grochot-Przęczek A, Józkowicz A, Nowak WN. Proximity Ligation Assay Detection of Protein–DNA Interactions—Is There a Link between Heme Oxygenase-1 and G-quadruplexes? Antioxidants. 2021; 10(1):94.
Kopacz A, Kloska D, Targosz-Korecka M, Zapotoczny B, Cysewski D, Personnic N, Werner E, Hajduk K, Jozkowicz A, Grochot-Przeczek A. Keap1 governs ageing-induced protein aggregation in endothelial cells. Redox Biol. 2020 Jul;34:101572.
Bednarz A, Lipiński P, Starzyński RR, Tomczyk M, Kraszewska I, Herman S, Kowalski K, Gruca E, Jończy A, Mazgaj R, Szudzik M, Rajfur Z, Baster Z, Józkowicz A, Lenartowicz M. Exacerbation of Neonatal Hemolysis and Impaired Renal Iron Handling in Heme Oxygenase 1-Deficient Mice. Int J Mol Sci, 2020, 21(20):7754
Schaum N, Lehallier B, Hahn O, Pálovics R, Hosseinzadeh S, Lee SE, Sit R, Lee DP, Losada PM, Zardeneta ME, Fehlmann T, Webber JT, McGeever A, Calcuttawala K, Zhang H, Berdnik D, Mathur V, Tan W, Zee A, Tan M; Tabula Muris Consortium, Pisco AO, Karkanias J, Neff NF, Keller A, Darmanis S, Quake SR, Wyss-Coray T. Ageing hallmarks exhibit organ-specific temporal signatures. Nature. 2020 583(7817):596-602
Tabula Muris Consortium. A single-cell transcriptomic atlas characterizes ageing tissues in the mouse. Nature. 2020, 583(7817):590-595
Brulois K*, Rajaraman A*, Szade A*, Nordling S*, Bogoslowski A, Dermadi D, Rahman M, Kiefel H, O’Hara E, Koning JJ, Kawashima H, Zhou B, Vestweber D, Red-Horse K, Mebius RE, Adams RH, Kubes P, Pan J, Butcher EC A molecular map of murine lymph node blood vascular endothelium at single cell resolution Nat Commun 2020 Jul 30;11:3798. doi: 10.1038/s41467-020-17291-5
Kopacz A, Kloska D, Forman HJ, Jozkowicz A, Grochot-Przeczek A. Beyond repression of Nrf2: An update on Keap1. Free Radic Biol Med. 2020; pii: S0891-5849(19)32525-0
Targosz-Korecka M, Malek-Zietek KE, Kloska D, Rajfur Z, Stepien EŁ, Grochot-Przeczek A, Szymonski M. Metformin attenuates adhesion between cancer and endothelial cells in chronic hyperglycemia by recovery of the endothelial glycocalyx barrier. Biochim Biophys Acta Gen Subj, 2020; 1864(4):129533
Gulati GS, Zukowska M, Noh JJ, Zhang A, Wesche DJ, Sinha R, George BM, Weissman IL, Szade K.
Neogenin-1 distinguishes between myeloid-biased and balanced Hoxb5 + mouse long-term hematopoietic stem cells. PNAS 2019: 116 (50) 25115-25125 i
Rozga P., Kloska D., Pawlak S., Teska-Kaminska M., Galazka M., Bukato K., Pieczykolan A., Jaworski A, Molga A., Kopacz A., Badyra B., Kachamakova-Trojanowska N., Zolnierkiewicz O., Targosz-Korecka M., Poleszak K.,
Szymanik M., Zerek B., Pieczykolan J., Jozkowicz A., Grochot-Przeczek A. Novel engineered TRAIL-based chimeric protein strongly inhibits tumor growth and bypasses TRAIL resistance. Int J Cancer, 2019, doi: 10.1002/ijc.32845
Szade A., Szade K., Nowak W.N., Bukowska-Strakova K., Muchova L., Gońka M., Żukowska M., Cieśla M., Kachamakova-Trojanowska N., Rams-Baron M., Ratuszna A., Dulak J., Józkowicz A. Cobalt protoporphyrin IX increases endogenous G-CSF and mobilizes hematopoietic stem cells and granulocytes to the blood. EMBO Mol Med, 2019: e09571.
Nowak W.N., Taha H., Markiewicz J., Kachamakova-Trojanowska N., Stępniewski J., Klóska D., Florczyk-Soluch U., Niżankowski R., Frołow M., Walter Z., Dulak J., Józkowicz A. Atorvastatin enhances the paracrine proangiogenic activity of hematopoietic stem/progenitor-derived cells in vitro but not in vivo. Mediat Inflammat, 2019: 1868170.
Bednarz A., Lipiński P., Starzyński R., Tomczyk M., Nowak W., Mucha O., Ogórek M., Pierzchała O., Jończy A., Staroń R., Śmierzchalska J., Rajfur Z., Baster Z., Józkowicz A., Lenartowicz M. Role of the kidneys in the redistribution of heme-derived iron during neonatal hemolysis in mice. Sci Rep, 2019, 9: 11102.
Nowak W.N., Taha H., N. Kachamakova-Trojanowska N., Stepniewski J., Markiewicz J., Kusienicka A., Szade K., Szade A., Bukowska-Strakova K., Hajduk K., Klóska D., Kopacz A., Grochot-Przeczek A., Barthenheier K., Cauvin C., Dulak J., Jozkowicz A. Murine bone marrow mesenchymal stromal cells respond efficiently to oxidative stress despite the low level of heme oxygenases 1 and 2. Antioxid Redox Signal, 2018, 29: 111-127.
Bukowska-Strakova K., Szade K., Nowak W., Ciesla M., Straka R., Szade A., Tyszka-Czochara M., Najder K., Konturek A., Siedlar M., Dulak J., Jozkowicz A. Heme oxygenase 1 affects granulopoiesis in mice through control of myelocyte proliferation but not differentiation of granulocytic precursors. Immunobiology, 2017, 222: 506-517.
Kachamakova-Trojanowska N., Nowak W., Szade K., Stepniewski J., Bukowska-Strakova K., Zukowska M., Taha H., Chmura-Skirlinska A., Beilharz M., Dulak J., Jozkowicz A. Generation of functional endothelial cells with progenitor-like features from murine induced pluripotent stem cells. Vasc Pharmacol, 2016, 86: 94-108.
Ciesla M., Marona P., Kozakowska M., Jez M., Seczynska M., Loboda A., Bukowska-Strakova K., Szade A., Walawender M., Kusior M., Stępniewski J., Szade K., Krist B., Yagensky O., Urbanik A., Kazanowska B., Dulak J., Jozkowicz A. Heme oxygenase-1 controls an HDAC4-miR-206 pathway of oxidative stress in rhabdomyosarcoma. Cancer Res, 2016, 76: 5707-5718.
Szade K., Zukowska M., Jozkowicz A., Dulak J. Measuring ATP concentration in a small number of murine hematopoietic stem cells. Methods Mol Biol, 2016, 1516: 205-217.
Kotlinowski J., Jozkowicz A. PPARγ and angiogenesis – endothelial cell perspective. J Diabet Res, 2016: 8492353.
Kotlinowski J., Grochot-Przeczek A., Taha H., Kozakowska M., Pilecki B., Skrzypek K., Bartelik A., Derlacz R., Horrevoets A.J.G., Pup A., Nagy L., Dulak J., Jozkowicz A. PPARγ activation but not PPARγ haplodeficiency affects proangiogenic potential of endothelial cells and bone marrow-derived progenitors. Cardiovasc Diabetol, 2014, 13: 150-169.
Grochot-Przeczek A., Kotlinowski J., Kozakowska M., Starowicz K., Jagodzinska J., Stachurska A., Volger O.L., Bukowska-Strakova K., Florczyk U., Tertil M., Jazwa A., Szade K., Stepniewski J., Loboda A., Horrevoets A.J.G., Dulak J., Jozkowicz A. Heme oxygenase-1 is required for angiogenic function of the bone marrow-derived progenitor cells: role in therapeutic revascularization. Antioxid Redox Signal, 2014, 20: 1677-1992.
Nowak W.N., Borys S., Kusinska K., Bukowska-Strakova K., Witek P., Koblik T., Jozkowicz A., Malecki M.T., Dulak J. Number of circulating cells, growth factor and antioxidative gene profiles may be altered in type-2 diabetes with and without diabetic foot syndrome. J Diabetes Invest, 2014, 5: 99-107.
Kozakowska M., Ciesla M., Stefanska A., Skrzypek K, Was H, Jazwa A, Grochot-Przeczek A, Kotlinowski J,Szymula A, Sierpniowska A, Mazan M., Yagensky O., Florczyk U., Lemke K., Zebzda A., Dyduch G., NowakW., Majka M., Derlacz R., Loboda A., Dulak J., Jozkowicz A. Heme oxygenase-1 inhibits myoblast differentiation by targeting myomirs. Antioxid Redox Signal. 2012, 16: 113-127.
Was H., Sokolowska M., Sierpniowska A., Dominik P., Skrzypek K., Lackowska B., Pratnicki A., Grochot-Przeczek A., Taha H., Kotlinowski J., Kozakowska M., Mazan A., Nowak W., Muchova L., Vitek L., Ratajska A., Dulak J., Jozkowicz J. Effect of heme oxygenase-1 on induction and development of chemically-induced squamous cell carcinoma in mice. Free Radic Mol Biol. 2011, 51: 1717-1726.
Taha H., Skrzypek K., Guevara I., Nigisch A., Mustafa S., Grochot-Przeczek A., Ferdek P., Was H., KotlinowskiJ., Kozakowska M., Balcerczyk A., Muchova L., Vitek L., Weigel G., Dulak J., Jozkowicz A. Role of heme oxygenase-1 in human endothelial cells – lesson from the promoter allelic variants. Arterioscler Thromb Vasc Biol 2010, 30: 1634-1641.
Was H., Dulak J., Jozkowicz A. Heme oxygenase in tumor biology and therapy. Current Drug Targets 2010, 11: 1551-1570.
Grochot-Przeczek A., Dulak J., Jozkowicz A. Heme oxygenase-1 in neovascularization: a diabetic perspective. Thromb Haemos, 2010, 104: 424-431.
Taha H., Grochot-Przeczek A., Was H., Kotlinowski J., Kozakowska M., Marek A., Skrzypek K., Lackowska B., Balcerczyk A., Mustafa S., Dulak J., Jozkowicz A. Modulation of inflammatory response bypentoxifylline is independent of heme oxygenase-1 pathway. J Physiol Pharmacol 2009, 60: 3-12.
Grochot-Przeczek A., Lach R., Mis J., Skrzypek K., Gozdecka M., Sroczynska P., Dubiel M., Rutkowski A., Kozakowska M., Zagorska A., Walczynski J., Was H., Kotlinowski J., Drukala J., Kurowski K., Kieda C., Herault Y., Dulak J., Jozkowicz A. Heme oxygenase-1 accelerates cutaneous wound healing in mice. PLoS One 2009, 4: e5803.
Jozkowicz A., Was H., Taha H., Kotlinowski J., Mleczko K., Cisowski J., Weigel G., Dulak J. 15d-PGJ2 upregulates synthesis of IL-8 in endothelial cells through induction of oxidative stress. Antioxidant Redox Signal 2008, 10: 2035-2046.
Deshane J., Chen S., Caballero S., Grochot-Przeczek A., Was H., Lach R., Hill-Kapturczak N., Siegal G.P., Dulak J., Jozkowicz A., Grant M.B., Agarwal A. Stromal cell-derived factor-1 promotes angiogenesis via heme oxygenase-1 dependent mechanism. J Exp Med, 2007, 204: 605-618.
Jozkowicz A., Waś H., Dulak J. Heme oxygenase-1 in tumors: is it a false friend? Antioxidant Redox Signal 2007, 9: 2099-2018.
Was H., Cichon T., Smolarczyk R., Rudnicka D., Stopa M., Chevalier C., Leger J.J., Lackowska B., Grochot A.,Bojkowska K., Ratajska A., Kieda C., Szala S., Dulak J., Jozkowicz A. Overexpression of hemeoxygenase-1 in murine melanoma: increased proliferation and viability of tumor cells, decreased survival of mice. Am J Pathol 2006, 169: 2181-2198.
Funovics P., Brostjan C., Nigisch A., Fila A., Grochot A., Mleczko K., Was H., Weigel G., Dulak J., JozkowiczA. 2006. Effects of 15d-PGJ2 on VEGF-induced angiogenic activities and expression of VEGF receptors in endothelial cells. Prostaglandin Other Lipid Mediat 79: 230-244.
Józkowicz A., Nigisch A., Węgrzyn J., Weigel G., Huk I., Dulak J. 2004. Opposite effects of prostaglandin-J2 onVEGF in normoxia and hypoxia: role of HIF-1. Biochim Biophys Res Commun 314: 31-38.
Dulak J., Schwartzacher SP, Zwick RH, Alber H., Millonig G., Weiss C., Hugel H., Frick M., Jozkowicz A., Pachinger O., Weidinger F. 2005. Effects of local gene transfer of VEGF-A on neointima formation after balloon injury in hypercholesterolemic rabbits. Vasc Med, 10: 285-291.
Józkowicz A., Dulak J. 2005. Helper-dependent adenoviral vectors in experimental gene therapy. Acta Biochim Pol, 326: 670-676.
Józkowicz A., Nigisch A., Winter B., Weigel G., Huk I., Dulak J. 2004. 15-deoxy-delta 12,14 -prostaglandin-J2 inhibitsexpression of eNOS in human endothelial cells. Prostaglandin Other Lipid Mediat 74: 11-28.
Dulak J., Łoboda A., Zagórska A., Józkowicz A. 2004. Complex role of heme oxygenase-1 in angiogenesis. Antioxidant Redox Signal 6: 868-866.
Dulak J., Józkowicz A. 2003. Regulation of vascular endothelial growth factor synthesis by nitric oxide: facts and controversies. Antioxidant Redox Signal 5: 123-132.
Józkowicz A., Huk I., Nigisch A., Weigel G., Dietrich W., Motterlini R., Dulak J. 2003. Heme oxygenase and angiogenic activity of endothelial cells: stimulation by carbon monoxide, inhibition by tin protoporphyrin-IX. Antioxidant Redox Signal 5: 155-162.
Józkowicz A., Huk I., Nigisch A., Weigel G., Weidinger F., Dulak J. 2002. Effect of prostaglandin-J2 on VEGF synthesis depends on the induction of heme oxygenase-1. Antioxidant Redox Signal 4: 577-585.
Kim I.H., Józkowicz A., Piedra P.A., Oka K., Chan L. 2001. Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector. Proc Natl Acad Sci USA 98: 13282-13287.
Józkowicz A., Dulak J., Nigisch A., Winter B., Weigel G., Nanobashwili J., Prager M., Huk I. 2001. Prostaglandin-J2 induces the synthesis of interleukin-8 by endothelial cells in a PPARg-independent manner. Prostaglandins Other Lipid Mediat 66: 165-177.
Józkowicz A., Cooke J.P., Guevara I., Huk I., Funovics P., Pachinger O., Weidinger F., Dulak J. 2001. Genetic augmentation of nitric oxide synthase increases the vascular generation of VEGF. Cardiovasc Res 51: 773-783.
Józkowicz A., Dulak J., Piatkowska E., Placha W., Dembińska-Kieć A. 2000. Ligands of peroxisome proliferator-activated receptor-γ increase the generation of vascular endothelial growth factor in vascular smooth muscle cells and in macrophages. Acta Biochem Pol 47: 1147-1157.